A US drone struck a suspected Al-Qaeda target in the Sanhan district southeast of Yemen's capital Sanaa on Wednesday night, tribal sources said.
The airstrike was reported in the village of Al-Sirain, they said.
"A US drone destroyed a car near the village killing a suspected Al-Qaeda operative and injuring another suspected militant," they said.
The killed was identified as Adnan Al-Qadi and the injured was taken to hospital, they continued.
It is the second time that US drones carry out airstrikes in northern Yemen since the US started to provide direct support to the country to fight AQAP and its offshoot militants in southern and southeastern regions.
Late last month, a US drone targeted a house of militants in Saada province on the border with Saudi Arabia killing at least four suspects.
The Yemeni army launched a US-backed offensive earlier this year driving Al-Qaeda militants out of their strongholds in Abyan and Shabwa provinces.
Hundreds of militants including senior leaders were killed, injured and arrested during the offensive.
Meanwhile, the US drones have been largely contributing to the war targeting key Al-Qaeda operatives and positions within the US direct support to hunt terrorists across the republic of Yemen.