At least 62 suspected al-Qaeda prisoners escaped from the central security prison in the southern city of Mukalla Wednesday morning.
One security personnel was killed as well as a prisoner. The security official said that a number of the escaped prisoners were arrested after coming back from Iraq, where they were fighting American forces.
This is considered the biggest prison breakout for suspected al-Qaeda suspects.
Opposition forces are blaming senior military officials with close links to President Saleh for allowing and easing the escape of al-Qaeda prisoners to cause chaos in the south and get more US support and prolong the Saleh regime.
This comes at the time where the assistant secretary of state is visiting Yemen.
He said the the majority of the escapees had court sentences of over five years in prison on terror charges.