Several patients were injured after an airstrikes hit the Hidan hospital in Yemen's province of Saada on Tuesday.
The Saba news agency quoted director of the district of Hidan Ali Moghli as saying the strikes destroyed the hospital completely.
"It was the last hospital operating in the province which has received the largest airstrikes since the Saudi-led military bombing campaign began in March," he said.
Many civilians were killed and injured in airstrikes in the cities of Saada, Taiz and Sanaa today, according to the agency.
Separately, the United Nations Humanitarian Coordinator for Yemen Johannes Van Der Klaauw urged to protect civilians and public infrastructure in accordance with the international laws.
He reiterated the warning that the continuing conflict and blockade are deepening the suffering of the Yemeni people while calling for urgent and unconditional delivery of aid to millions of people.
The several-months conflict including the blockade on all sea, land and air routes has left 80% of the country's population in need of emergency aid.
The blockade was part of the military intervention and has deprived Yemen of all supplies especially foods and medicines.